ea0092op-13-05 | Oral Session 13: Pathophysiological actions of thyroid hormones | ETA2023
Kowalczyk Manuela
, Flamant Frederic
, Gauthier Karine
, Lange Christian
, Moller Lars
, Zwanziger Denise
Objectives: Acute liver failure (ALF) is a rare but life-threatening condition with severe liver dysfunction. In ALF liver regeneration capacity is exceeded due to loss of hepatocyte function. A well-known trigger of ALF is paracetamol (acetaminophen, APAP) intoxication. Unfortunately, based on the poor prognosis and rapidly increasing mortality rate liver transplantation offers the so far only effective therapeutic strategy. Even if the underlying mechanisms of ALF are not ye...